tag:blogger.com,1999:blog-2909827059962062852.post1438353244560712707..comments2024-03-26T17:10:36.305+00:00Comments on Molecular Design: Molecular Complexity (follow up)Peter Kennyhttp://www.blogger.com/profile/12180360326821860667noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-2909827059962062852.post-60374547043587014622009-01-25T15:45:00.000+00:002009-01-25T15:45:00.000+00:00Thanks for ur invitation and the info is really in...Thanks for ur invitation and the info is really interesting about FBDD and as I wanted to compare HTS and FBDD., really helpful. Thanx. Pete.https://www.med-chemist.comhttps://www.blogger.com/profile/00786134978315983333noreply@blogger.comtag:blogger.com,1999:blog-2909827059962062852.post-3538964285930940832009-01-25T15:41:00.000+00:002009-01-25T15:41:00.000+00:00Though I am new to this field. Its really interes...Though I am new to this field. Its really interesting info. I was trying to understand FBDD, HTS and compare these two aspects of drug discovery. Thanx for the detailed info....https://www.med-chemist.comhttps://www.blogger.com/profile/00786134978315983333noreply@blogger.comtag:blogger.com,1999:blog-2909827059962062852.post-16086998378125175262009-01-21T14:47:00.000+00:002009-01-21T14:47:00.000+00:00Peter - glad to see the old paper having some air ...Peter - glad to see the old paper having some air time! One thing that I could add is around how to think of Ligand Efficiency within our model. My way of thinking of this is that the probability curve for the chance of detection (the one that goes from 0 to 1) is moved to the left for more ligand efficient compounds. ie there is a higher chance of the measurement (by whatever method you choose) working for a less complex compound. The effect of this on the "chance of useful event" curve is also to move it to the left and most importantly to increase its value so there is a higher chance of the useful event. One day I hopet to get to putting this in a paper of follow up thoughts but in the meantime will share with this new community in the hope of provoking some more discussion! MikeMolecular Simpletonhttps://www.blogger.com/profile/06230615293196799745noreply@blogger.com