Showing posts with label LE. Show all posts
Showing posts with label LE. Show all posts
Thursday, 8 June 2023

Archbishop Ussher's guide to efficient selection of development candidates

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One piece of advice I gave in NoLE is that “drug designers should not automatically assume that conclusions drawn from analysis of large, s...
Sunday, 2 August 2020

Why fragments?

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Paramin panorama Crystallographic fragment screens have been run recently against the main protease (at Diamond ) and the Nsp3 macrodomain (...
4 comments:
Saturday, 11 May 2019

Efficient trajectories

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I'll examine an article entitled ‘Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations’ (YL2018) in t...
Friday, 8 February 2019

The nature of ligand efficiency

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"First they ignore you, then they laugh at you ,  then they fight you , then you win " (Sometimes attributed to Mahatma Gand...
2 comments:
Sunday, 27 January 2019

Reviewing the reviewers

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I recently published The Nature of Ligand Efficiency (NoLE) as a ChemRxiv preprint and this was featured (for all the right reasons) in ...
Friday, 30 November 2018

Ligand efficiency and fragment-to-lead optimizations

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The third annual survey (F2L2017) of fragment-to-lead (F2L) optimizations was published last week. Given that it was the second survey ...
4 comments:
Friday, 6 January 2017

Confessions of a Units Nazi

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Regular readers (both of them) of this blog will know that I have an interest, which some might term an obsession, with units. At high scho...