Molecular Design

Controlling the behavior of compounds and materials by manipulation of molecular properties.

Showing posts with label hit-to-lead. Show all posts
Showing posts with label hit-to-lead. Show all posts
Wednesday, 31 December 2025

Hit to Lead best practice?

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I'm now in Trinidad and I'll share a 180° panorama from Paramin where I walk for exercise. This district in Trinidad's Northern ...
Sunday, 2 August 2020

Why fragments?

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Paramin panorama Crystallographic fragment screens have been run recently against the main protease (at Diamond ) and the Nsp3 macrodomain (...
4 comments:
Friday, 30 November 2018

Ligand efficiency and fragment-to-lead optimizations

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The third annual survey (F2L2017) of fragment-to-lead (F2L) optimizations was published last week. Given that it was the second survey ...
4 comments:
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