Molecular Design

<< previous || next >> I sometimes wonder what percentage of the pharmacopoeia will have been proposed for repurposing for ...

Paramin panorama Crystallographic fragment screens have been run recently against the main protease (at Diamond ) and the Nsp3 macrodomain (...

<< previous || next >> “Just take the ball and throw it where you want to. Throw strikes. Home plate don’t move.” Satchel P...

|| next >> It’s been ages since the last blog post. I’d been thinking of marking my return with an April Fools post but this didn’t ...

"A theory has only the alternative of being right or wrong. A model has a third possibility: it may be right, but irrelevant." ...

I'll examine an article entitled ‘Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations’ (YL2018) in t...

I've started using Figshare and have uploaded my first two harangues. Late last month, I did a talk on ligand efficiency at Evotec U...