Saturday, 1 April 2023

A clear demonstration of the benefits of long residence time

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<< previous || next >> Residence time is a well-established concept in drug discovery and the belief that off-rate is more imp...
2 comments:
Wednesday, 22 February 2023

Structural alerts and assessment of chemical probes

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 << previous | I’ll wrap up (at least for now) the series of posts on chemical probes by returning to the use of cheminformatic model...
1 comment:
Wednesday, 15 February 2023

Frequent-hitter behavior and promiscuity

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I’ll be discussing promiscuity in this post and, if there’s one thing that religious leaders and drug discovery scientists agree on, it’s th...
7 comments:
Wednesday, 8 February 2023

Chemical probes and permeability

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<< previous || next >> I’ll start this post by with reference to a disease that some of you many never have heard of. Chagas d...
Saturday, 28 January 2023

More approaches to design of covalent inhibitors of SARS-CoV-2 main protease

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<< previous | I’ll pick up from the previous post on design covalent inhibitors of SARS-CoV-2 main protease (structure and chart num...
Wednesday, 25 January 2023

Assessment of chemical probes: response to Practical Fragments

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<< previous | next >> I had originally intended to look at permeability in this post but I do need to respond to Dan Erlanson’...
Thursday, 19 January 2023

Some approaches to design of covalent inhibitors of SARS-CoV-2 main protease

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<< previous | next >> I last posted on Covid-19 early in 2021 and quite a lot has happened since then. Specifically, a number...