tag:blogger.com,1999:blog-2909827059962062852.post7436279981659222807..comments2024-03-26T17:10:36.305+00:00Comments on Molecular Design: SARS-CoV-2 main protease. Crowdsourcing, peptidomimetics and fragmentsPeter Kennyhttp://www.blogger.com/profile/12180360326821860667noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-2909827059962062852.post-64631545888509801752020-08-12T13:02:55.583+01:002020-08-12T13:02:55.583+01:00You make good points, Chris, and I wouldn’t disagr...You make good points, Chris, and I wouldn’t disagree. My view is that the term ‘open source’ is primarily used in the drug discovery context for promotion and propaganda (this is no way intended as criticism of what drug discovery programs that are described as ‘open source’ are trying to achieve) and I’d advise those trying to do drug discovery openly to ditch the term. There are huge differences between pharmaceutical products and software products and I do not find the ‘explanations’ for what constitutes ‘source’ for a pharmaceutical product to be remotely convincing. If memory serves me correctly, one of the initial arguments for open source in drug discovery was that open source worked for linux so it’s got to work for drug discovery. I see getting the necessary resources and coordination (i.e. using resources efficiently) to be the principal challenges for open approaches to drug discovery. Peter Kennyhttps://www.blogger.com/profile/12180360326821860667noreply@blogger.comtag:blogger.com,1999:blog-2909827059962062852.post-69838582762150962772020-08-11T19:26:14.779+01:002020-08-11T19:26:14.779+01:00Good stuff but minor quibble in that OSDD is not O...Good stuff but minor quibble in that OSDD is not OSDD. Their chemistry is not "open" and CSIR seeks IP, whereas OSM certainly is (quote from Mat Todd PMID 31612602 "The Open Source Drug Discovery project in India was, despite its name, operating a crowdsourcing initiative as opposed to something that was open source"). It is somewhat ironic that MMV filed patents on all their lead compounds (i.e. not strictly OSDD) but their new Malaria Libre initiative now takes the OSM precedentBio to Chemhttps://www.blogger.com/profile/02917489256174950727noreply@blogger.com