Thursday, 20 November 2008

A few more general review articles on FBDD

Current Opinion in Chemical Biology has published several mini reviews in FBDD.  This one by the folks at Astex is short, but touches on both NMR and X-ray crystallographic approaches to FBDD:

Jhoti H, et al.  Fragment-based screening using X-ray crystallography and NMR spectroscopy.  Curr Opin Chem Biol. (2007) 11:485-493

In the same vein is a paper from Teddy Zartler at Merck that also discusses the concept of ligand efficiency in FBDD:

Zartler ER and MJ Shapiro.  Fragonomics: fragment-based drug discovery. Curr Opin Chem Biol. (2005) 9:366-370  

Tethering, an alternate approach to FBDD pioneered by Sunesis Pharmaceuticals, is discussed in this review: 

Erlanson DA and SK Hansen.  Making drugs on proteins: site-directed ligand discovery for fragment based assembly.  Curr Opin Chem Biol.  (2004) 8:399-406.

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