Lipophilicity and Pharmacological Promiscuity

We often hear and read that pharmacological promiscuity is strongly correlated with lipophilicity and it's often a good idea to check that the dogma matches the data. I set up a poll (which closed just over a week ago) for the LinkedIn FBDD group that asked the question:

Is pharmacological promiscuity strongly correlated with lipophilicity?

And the responses were: Yes (43 votes), No (5 votes) and Don't Know (2 votes)

Although the poll is now closed, we're still discussing the results so why not come and join the fun.