Biochemical assays can have high throughput and are relatively inexpensive to run.
Shapiro, Walkup and Keating Correction for Interference by Test Samples in High-Throughput Assays. J. Biomol. Screen. 2009, 14, 1008-1016 | DOI | Review
Hesterkamp et al, Fragment based drug discovery using fluorescence correlation spectroscopy techniques: Challenges and solutions. Curr. Top. Med. Chem. 2007, 7, 1582-1591 Link
Barker et al, Fragment screening by biochemical assay. Expert Opin. Drug Discov. 2006, 1, 225-236 DOI