Tuesday, 2 December 2008

X-ray Crystallography

X-ray crystallography can be used to screen fragments.

Hartshorn et al, Fragment-Based Lead Discovery Using X-ray Crystallography J. Med. Chem. 2005, 48, 403-413 DOI

Nienaber et al, Discovering novel ligands from macromolecules using X-ray crystallographic screening. Nature Biotech. 2000, 18, 1105-1108. DOI

Allen et al, An Experimental Approach to Mapping the Binding Surfaces of Crystalline Proteins J. Phys. Chem., 1996, 100, 2605–2611 DOI

1 comment:

Egon Willighagen said...

I hope future literature cites will have a bit more comment on it? Otherwise, it is better to just use citeulike.org or so... put things in some perspective...