Wednesday, 4 June 2014

Ligand efficiency metric teaser

Here's a bit of fun. See how these parallel lines transform when you divide Y by X (this is how you calculate ligand efficiency).

Here's some more fun. See how these lines transform when you subtract X from Y (this is how you calculate lipophilic efficiency.

Would you consider activities lying on a straight line when plotted against molecular size or lipophilicity to represent compounds with the same efficiency?